| Date | Place | Country | Cont. | Name of Building | By Whom | Date |
| Begun | Or publication, event | Architect, Engineer, Author | Compl. | |||
| 1500 | Brazil | LA | Discovered by Pedro Cabral | |||
| 1500 | Querétaro | Mexico | LA | Spanish Aqueduct | 1600 | |
| 1500 | Cuzco | Peru | LA | Fortress of Sacsahuaman, Inca Masonry Wall | ||
| 1502 | Venice | Italy | E | Palazzo Loredan (later Vendramin-Calergi) | Mauro Codussi | |
| 1503 | Seville | Spain | E | Casa de Contratacion established: beginnings of Colonial Government | ||
| 1503 | London | E | Henry VIIth Chapel at Westminster Cathedral | WilliamVertue | 1519 | |
| 1503 | Rome | E | Masterplan of Rome | Donato Bramante | 1513 | |
| 1504 | Cairo | Egypt | AF | Caravanserai of Qansuh-al-Ghuri | 1505 | |
| 1504 | Santo Domingo | Dominican Republlic | C | Convent of San Francisco | 1547 | |
| 1504 | Rome | E | Tempietto in the monastery of S Pietro in Montorio | Donato Bramante (1444-1514) | ||
| 1505 | Rome | E | Vatican, Cortile del Belvedere | DonatoBramante | ||
| 1506 | Rome | E | Plan for St Peter's | Bramante | ||
| 1509 | Santo Domingo | Dominican Republic | C | Diego's Gate | ||
| 1509 | Sevilla la Nueva | Jamaica | C | Town Founded by the Spanish | ||
| 1509 | Rome | E | Vatican, School of Athens, Mural | Raphael | 1511 | |
| 1510 | Santo Domiingo | Dominican Republic | C | Alcazar, palace of Diego Columbus | ||
| 1510 | Mexico City | Mexico | LA | Tenochtitlan complex | c. | |
| 1511 | Cuba | C | First Spanish settlers arrive | |||
| 1512 | Rome | E | Palazzo Caprini or House of Raphael | Bramante | ||
| 1513 | Florence | Italy | E | Macchiavelli write The Prince | ||
| 1513 | Rome | E | Accession of Leo X, zenith of Renaissance Rome | |||
| 1513 | OC | Balboa discovers the Pacific | ||||
| 1514 | Chaldiran | Persia | ME | beginning of wars between Persia and Turkey | ||
| 1515 | France | E | François I becomes King of France | |||
| 1516 | Algiers | AF | Taken by Barbarossa | |||
| 1517 | Wittenberg | Germany | E | Luther nails his 95 theses to the door of the church: beginning of the Reformation | ||
| 1519 | Amboise | France | E | Death of Leonardo da Vinci | ||
| 1519 | Germany/ Spain | E | Charles V inherits Hapsburg lands | |||
| 1519 | Portugal | E | Ferdinand Magellan begins circumnavigation of the world | |||
| 1520 | Chambord | France | E | Royal Chateau | Domenico da Cortona(?) | |
| 1520 | Tomar | Portugal | E | Convent of Christ, window of chapterhouse | Diego da Arruda | |
| 1520 | Istanbul | Turkey | ME | Suleiman the Magnificent becomes Sultan | ||
| 1521 | Santo Domingo | Dominican Republic | C | Cathedral of Santa Maria la Menor | 1541 | |
| 1521 | Worms | Germany | E | Diet of Worms:Luther commits himself to protestantism | ||
| 1521 | Mexico | LA | Conquered by Hernando Cortes | |||
| 1523 | Spanish Town | Jamaica | C | Founded by the Spanish as St Jago de la Vega | ||
| 1523 | San Juan | Puerto Rico | C | San José Church | ||
| 1523 | San Juan | Puerto Rico | C | Casa Blanca | 1527 | |
| 1523 | Cordoba | Spain | E | Church built in the Great Mosque | ||
| 1526 | Panipat | India | AS | Babar begins moslem conquest of India | ||
| 1526 | Mantua | Italy | E | Palazzo del Té | Giulio Romano | 1534 |
| 1527 | Curaçao | C | Settled by the Spanish | |||
| 1527 | Granada | Spain | E | Alhambra, Palace of CharlesV | Pedro Machuca | 1568 |
| 1527 | Rome | E | Sacked by troops of Charles V | |||
| 1528 | Fontainebleau | France | E | Royal Chateau | Gilles le Breton | |
| 1529 | Vienna | Austria | E | Sieged by the Turks | ||
| 1529 | Speyer | Germany | E | Diet of Speyer: origin of the name Protestant | ||
| 1530 | Rome | E | Palazzo Farnese | Antonio da Sangallo the Younger | 1589 | |
| 1532 | Peru | LA | Conquered by Francisco Pizarro | |||
| 1533 | Russia | E | Ivan IV becomes Tsar | |||
| 1534 | England | E | Act of Supremacy: Henry VIII asserts control over church: Start of the Anglican church | |||
| 1536 | England | E | Dissolution of the monasteries | 1539 | ||
| 1536 | Venice | Italy | E | Library on the Piazza San Marco | Jacopo Sansovino | |
| 1537 | Rome | E | Campidoglio design | Michelangelo Buonaroti | ||
| 1540 | San Juan | Puerto Rico | C | La Fortaleza | ||
| 1540 | San Juan | Puerto Rico | C | San Juan Cathedral | ||
| 1540 | Rome | E | Society of Jesus: The Jesuit Order recognized by the Pope | |||
| 1540 | USA | NA | Francisco de Coronado explores North America | |||
| 1541 | Geneva | Switserland | E | John Calvin regains authority over city | ||
| 1542 | Japan | AS | First Portuguese reach Japan | |||
| 1542 | Spain | E | New Laws of the Indies: 1st attempt to legislate for well-being of colonial natives | |||
| 1543 | Frauenburg | Germany | E | death of Nicolas Copernicus | ||
| 1544 | Istanbul | Turkey | ME | Shehzade Mosque, or Mosque of the Princes | Sinan | 1548 |
| 1545 | Trent | Italy | E | Council of Trent: beginning of Counter Reformation | ||
| 1546 | Vicenza | Italy | E | Palazzo Chiericati | Palladio | 1557 |
| 1546 | Rome | E | Plan for St Peter's | Michelangelo Buonaroti | ||
| 1546 | Rome | E | St Peter's | Michelangelo Buonaroti | 1564 | |
| 1546 | Paris | E | The Louvre, the Cour Carrée | Pierre Lescot | ||
| 1549 | England | E | English Book of Common Prayer | |||
| 1549 | Cholula | Mexico | LA | Franciscan Monastery Church of S Gabriel | 1552 | |
| 1550 | Maser | Italy | E | Villa Barbaro | Palladio | 1554 |
| 1550 | Istanbul | Turkey | ME | külliye of Suleyman I (the Magnificent) | Sinan | 1557 |
| 1551 | Piombino Dese | Italy | E | Villa Cornaro | Palladio | 1553 |
| 1552 | Gozleve | Cirmea | ME | Mosque of Mimar Sinan | Sinan | |
| 1555 | Havana | Cuba | C | City sacked by the French | ||
| 1557 | Macao | China | AS | Becomes permanent Portuguese port | ||
| 1558 | England | E | Accession of Queen Elizabeth I | |||
| 1560 | Vicenza | Italy | E | Villa Rotonda, Villa Capra | Palladio | |
| 1560 | Cholula | Mexico | LA | Capilla Real or Capilla de Indios | ||
| 1561 | Rome | E | design of Strada Pia & PortePia Now: Via XX Settembre | Michelangelo Buonaroti | ||
| 1562 | France | E | Wars of Religion begin | 1598 | ||
| 1563 | England | E | 39 articles define Elizabethan Church settlement | |||
| 1564 | England | E | Birth of Shakespeare | |||
| 1564 | Rome | Italy | E | Death of Michelangelo | ||
| 1565 | Vicenza | Italy | E | Palazzo Valmarana | Palladio | 1571 |
| 1567 | Netherlands | E | Spanish Duke of Alva in the Netherlands: start of the 80 years war | |||
| 1568 | Rome | E | il Gesu, interior | Giacomo Barozzi da Vignola | 1584 | |
| 1569 | Edirne | Turkey | ME | Selim Mosque | Sinan | 1575 |
| 1570 | Atlatlauhcan | Mexico | LA | Church | ||
| 1571 | Bornu or Kanem | Central Sudan | AF | achieves its zentih under Idris III | ||
| 1571 | Istanbul | Turkey | ME | Sokullu Mehmed Pasha Mosque | Sinan | |
| 1572 | France | E | Massacre of St Bartholomew; protestants killed | |||
| 1575 | Rome | E | Il Gesu, facade | GiacomodellaPorta | 1582 | |
| 1576 | France | E | Catholic League formed under Guise family | |||
| 1576 | Venice | Italy | E | Church of Il Redentore, (the Redeemer) | Andrea Palladio | 1580 |
| 1577 | England | E | Sir Francis Drake begins voyage around the world | 1580 | ||
| 1579 | Utrecht | Netherlands | E | Union of Utrecht: formation of Dutch Republic | ||
| 1579 | Turkey | ME | Death of Grand Vizier Sokolli: decline of Turkish power begins | |||
| 1580 | Vicenza | Italy | E | Teatro Olimpico | Palladio | 1585 |
| 1582 | Rome | E | Gregorian Calendar introduced by Pope Gregory XIII | |||
| 1584 | Havana | Cuba | C | San Francisco Convent | ||
| 1584 | Delft | Netherlands | E | Assasination of William the Silent | ||
| 1585 | Japan | AS | Hideyoshi becomes dictator and unifies the country | |||
| 1585 | Rome | E | Masterplan of Rome | 1590 | ||
| 1586 | Santo Domingo | Dominican Republic | C | Tostado House | before | |
| 1587 | Havana | Cuba | C | Lombillo Mansion, now Education Museum | ||
| 1587 | Persia | ME | Shah Abbas I (the Great) becomes ruler of Persia | |||
| 1589 | France | E | Death of Catherine de' Medici, Queen Mother of France | |||
| 1598 | France | E | Edict of Nantes: French protestants guaranteed liberty of worship | |||
| 1600 | Japan | AS | Tokugawa period begins, Ieyasu takes title of Shogun in 1603 | |||
| 1600 | Havana | Cuba | C | The House of the Arabs | c. | |
| 1600 | Cambridge | England | E | Trinity Hall | ||
| 1600 | England | E | England East India Comapany Founded | |||
| 1602 | Netherlands | E | Dutch East India Comapany founded | |||
| 1605 | Barbados | C | Claimed for the King of England | |||
| 1606 | San Germán | Puerto Rico | C | Porta Coeli Church | ||
| 1606 | Rome | E | St Peter's Main Facade | Carlo Maderno | 1612 | |
| 1606 | Rome | E | St Peter's Nave | Carlo Maderno | 1612 | |
| 1607 | Jamestown, Virginia | USA | NA | Virginia colonized by London Company, town founded | ||
| 1608 | Quebec | Canada | NA | Founded by Champlain | ||
| 1609 | Istanbul | Turkey | ME | Blue Mosque of Sultan Ahmed I | 1617 | |
| 1611 | England | E | Authorized Version of the Bible published | |||
| 1611 | Ireland | E | Ulster colonized by English and Scotish settlers | |||
| 1613 | Russia | E | Michael Romanov becomes Czar | |||
| 1613 | Paris | E | Hôtel Liancourt | Salomon de Brosse & Jacques Lemercier | 1623 | |
| 1614 | England | E | Napier publishes his explanation of logarithms | |||
| 1616 | England | E | Death of Shakespeare | |||
| 1616 | Italy | E | Edict of inquisition against Galileo's astronomy | |||
| 1616 | Spain | E | Death of Cervantes auth. of Don Quixote | |||
| 1616 | Paris | E | St. Gervais, facade | Salomon de Brosse | ||
| 1616 | London | E | The Queen's House, Greenwich | Inigo Jones | 1635 | |
| 1618 | Germany | E | Beginning of thirty years war | |||
| 1620 | USA | NA | Pilgrim fathers settle in New England | |||
| 1623 | Amsterdam | Netherlands | E | Noorder Kerk | ||
| 1623 | Paris | E | The Temple of Charenton | Salomon de Brosse | ||
| 1624 | St Kitts | C | British settlers taken to St Kitts by Sir Thomas Warnar | |||
| 1624 | Rome | E | St Peter's Baldacchino | Gianlorenzo Bernini | 1633 | |
| 1627 | Barbados | C | John Powell colonises the island with 80 settlers | |||
| 1628 | England | E | Harvey publishes his work on the ciculation of blood | |||
| 1629 | Bahamas | C | England Lays formal claim to the island | |||
| 1630 | London | E | St Paul's Covent Garden | Inigo Jones | 1631 | |
| 1630 | Isleta | New Mexico, USA | NA | San August in de la Isleta | ||
| 1632 | Antigua | C | British settlers move to Antigua from St Kitts & Nevis | |||
| 1634 | Curaçao | C | Taken over from the Spanish by the Dutch West India Company | |||
| 1635 | Fort St. Pierre | Martinique | C | city founded | ||
| 1636 | Japan | AS | Japanese forbidden to go abroad | |||
| 1637 | Russia | AS | Russian pioneers reach shores of Pacific | |||
| 1638 | St. Maarten/St. Martin | C | Dutch and French Settlers arrive but are driven out by the Spanish | |||
| 1639 | San Juan | Puerto Rico | C | San Juan Gate | ||
| 1639 | St Lucia | C | Settled by the British | |||
| 1640 | Barbados | C | First English Caribbean Island to start systematic plantation of Sugar Cane | |||
| 1640 | St Lucia | C | British settlers wiped out by native Caribs | |||
| 1641 | Japan | AS | Japanese exclude all foreigners except for a small Dutch trading fleet | |||
| 1641 | Ireland | E | Massacre of the protestants | |||
| 1642 | Basseterre | St Kitt's | C | La Fontaine | ||
| 1642 | England | E | Outbreak of English Civil War | |||
| 1643 | Havana | Cuba | C | Conent of Santa Clara | ||
| 1644 | China | AS | Ch'ing Dynasty | |||
| 1645 | Paris | France | E | Val de Grace, church | François Mansart & Jacques Lemercier | |
| 1648 | Eleuthera | Bahamas | C | English settlers arrive | ||
| 1648 | St. Martin/Sint Maarten | C | Dutch and French Settlers regain Possession of island and peacably divide the territory between them, founding Marigot (French) and Philipsburg (Dutch) | |||
| 1648 | Rome | Italy | E | Fontain of the four rivers, Piazza Navona | Gianlorenzo Bernini | 1651 |
| 1649 | England | E | Charles I executed | |||
| 1649 | England | E | Charles I is executed by Parliament | |||
| 1649 | The Hague | Netherlands | E | Nieuwe Kerk | ||
| 1649 | Russia | E | New code of laws establishes serfdom | |||
| 1650 | St. George Parish | Barbados | C | Drax Hall | c. | |
| 1650 | Grenada | C | Colonized by the French | |||
| 1650 | Istanbul | Turkey | ME | Topkapi Palace, Pavillion of Kara Mustafa Pasa | 1700 | |
| 1651 | San Juan | Puerto Rico | C | Gran Hotel Il Convento | ||
| 1652 | South Africa | AF | Founding of Dutch Cape Colony under van Riebeek | |||
| 1656 | Rome | Italy | E | Sta Maria della Pace | Pietro da Cortona | 1657 |
| 1656 | Turkey | ME | Grand Vizier Kiuprilli: revival of Turkish government | |||
| 1657 | Rome | Italy | E | St Peter's, Throne of St Peter, (Cathedra Petri) | Gianlorenzo Bernini | 1666 |
| 1657 | Boston | USA | NA | First Town House | 1658 | |
| 1658 | Rome | Italy | E | S Andrea al Quirinale | Gianlorenzo Bernini | 1670 |
| 1659 | France | E | Peace of the Pyrrenees, France replaces Spain as the greatest power in Western Europe | |||
| 1659 | France/ Spain | E | Peace of the Pyrannees: France displaces Spain as the greatest European power | |||
| 1660 | St Peter Parish | Barbados | C | St Nicholas Abbey | c. | |
| 1660 | England | E | Restoration of Monarchy with Charles II | |||
| 1660 | Versailles | France | E | The Palace of Versailles | Louis Le Vau, André Le Notre, Charles Lebrun, Jules Hardouin Mansart et al. | |
| 1662 | Rome | Italy | E | S Maria di Monte Santo & S Maria de' Miracoli | Carlo Rainaldi & others | 1679 |
| 1663 | Havana | Cuba | C | City walls | 1740 | |
| 1663 | Rome | Italy | E | S Maria in Campitelli | Carlo Rainaldi | 1667 |
| 1664 | New York | USA | NA | Taken by the English starting second Anglo Dutch War | ||
| 1664 | USA | NA | New York (New Amsterdam) taken by the English, 2nd Anglo-Dutch War | |||
| 1665 | London | England | E | Great Plague of London | ||
| 1665 | Rome | Italy | E | S Carlo alle Quattro Fontane | Francesco Borromini | 1667 |
| 1666 | London | England | E | Great Fire of London | ||
| 1666 | England | E | Isaac Newton disovers laws of gravitation | |||
| 1666 | London | England | E | Great Fire of London | ||
| 1666 | Cambridge | England | E | Newton's Discovery of the laws of Gravitation | ||
| 1666 | France | E | Academie à Rome founded | |||
| 1667 | Cap Haïtien | Haiti | C | City Founded by the Spanish | ||
| 1667 | Rome | Italy | E | Piazza of St Peter's | Gianlorenzo Bernini | |
| 1667 | Paris | France | E | East Facade of the Louvre | Claude Perrault & Louis Le Vau | 1670 |
| 1668 | Turin | Italy | E | San Lorenzo | Guarino Guarini | 1687 |
| 1668 | Rome | Italy | E | Ponte Sant' Angelo, (ancient Pons Aelius of 2nd c AD) | Gianlorenzo Bernini | 1671 |
| 1669 | Amsterdam | Netherlands | E | Death of Rembrandt van Rijn | ||
| 1670 | Ponce | Puerto Rico | C | Cathedral of OUr Lady of Guadeloupe | Francisco Porrata Doria | |
| 1670 | Paris | France | E | Hôtel des Invalides | Liberal Bruant | 1677 |
| 1671 | Paris | France | E | Academie Royale de l'architecture founded | ||
| 1672 | The Hague | Netherlands | E | Murder of the De Witt Brohers, William of Orange takes over. | ||
| 1672 | London | England | E | St Stephen Walbrook | Sir Christopher Wren | 1687 |
| 1673 | England | E | <